Products

Western Blot (Cell lysate)

CSTB monoclonal antibody (M01), clone M1-C1 Western Blot analysis of CSTB expression in MCF-7 ( Cat # L046V1 ).

Western Blot (Recombinant protein)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunoperoxidase of monoclonal antibody to CSTB on formalin-fixed paraffin-embedded human liver. [antibody concentration 3 ug/ml]

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged CSTB is approximately 1ng/ml as a capture antibody.

ELISA

Entrez GeneID

1476

GeneBank Accession#

BC003370.1

Protein Accession#

AAH03370.1

Gene Name

CSTB

Gene Alias

CST6, EPM1, PME, STFB

Gene Description

cystatin B (stefin B)

Omim ID

254800 601145

Gene Ontology

Hyperlink

Gene Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq

Other Designations

CPI-B|cystatin B|liver thiol proteinase inhibitor|stefin B