Products

Western Blot (Transfected lysate)

Western Blot analysis of CST6 expression in transfected 293T cell line by CST6 monoclonal antibody (M01), clone 2H8.

Lane 1: CST6 transfected lysate (Predicted MW: 16.5 KDa).
Lane 2: Non-transfected lysate.

Western Blot (Recombinant protein)

ELISA

Entrez GeneID

1474

GeneBank Accession#

BC031334

Protein Accession#

AAH31334

Gene Name

CST6

Gene Alias

-

Gene Description

cystatin E/M

Omim ID

601891

Gene Ontology

Hyperlink

Gene Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq

Other Designations

cystatin 6|cystatin M|cystatin M/E|cysteine proteinase inhibitor