IL15 (Human) ELISA Kit

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Specifications
Product Description
IL15 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human IL15.
Suitable Sample
Cell Culture Supernatant, Cell Lysates, Tissue Homogenates, Plasma (EDTA, heparin), Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
15.6 to 1000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — IL15
Entrez GeneID
3600Gene Name
IL15
Gene Alias
IL-15, MGC9721
Gene Description
interleukin 15
Omim ID
600554Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq
Other Designations
OTTHUMP00000164617
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Interleukin-15 production during liver allograft rejection in humans.
Conti F, Frappier J, Dharancy S, Chereau C, Houssin D, Weill B, Calmus Y.
Transplantation 2003 Jul; 76(1):210.
Application:ELISA, Human, Supernatants collected from PBMCs or monocytes culture medium, Plasma.
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Chromosomal assignment and genomic structure of Il15.
Anderson DM, Johnson L, Glaccum MB, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW, et al..
Genomics 1995 Feb; 25(3):701.
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Interleukin-15 production during liver allograft rejection in humans.
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