COMT polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of COMT.
Immunogen
A synthetic peptide corresponding to human COMT.
Sequence
GDTKEQRILNHVLQC
Host
Goat
Theoretical MW (kDa)
30, 24.5
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_000745.1 and NP_009294.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
COMT polyclonal antibody (Cat # PAB6722) (1 ug/mL) staining of human testis lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — COMT
Entrez GeneID
1312Protein Accession#
NP_000745.1;NP_009294.1Gene Name
COMT
Gene Alias
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Gene Description
catechol-O-methyltransferase
Gene Ontology
HyperlinkGene Summary
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond.
Tunbridge EM, Harrison PJ, Weinberger DR.
Biological Psychiatry 2006 Jul; 60(2):141.
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Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond.
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