APEX1 polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of Lane 1: Human cell line RT-4; Lane 2: Human cell line U-251MG sp; Lane 3: Human cell line A-431; Lane 4: Human liver tissue; Lane 6: Human tonsil tissue with APEX1 polyclonal antibody (Cat#PAB28591) at 1:100-1:250 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human small intestine with APEX1 polyclonal antibody (Cat#PAB28591) shows strong nuclear positivity in glandular cells at 1:200-1:500 dilution.
Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with APEX1 polyclonal antibody (Cat#PAB28591) at 4 ug/ml shows positivity in nucleus.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant APEX1.
Immunogen
Recombinant protein corresponding to amino acids of human APEX1.
Sequence
KLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLAD
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:100-1:250)
Immunofluorescence (1-4 ug/ml)
Immunohistochemistry (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: Human cell line RT-4; Lane 2: Human cell line U-251MG sp; Lane 3: Human cell line A-431; Lane 4: Human liver tissue; Lane 6: Human tonsil tissue with APEX1 polyclonal antibody (Cat#PAB28591) at 1:100-1:250 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human small intestine with APEX1 polyclonal antibody (Cat#PAB28591) shows strong nuclear positivity in glandular cells at 1:200-1:500 dilution.Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with APEX1 polyclonal antibody (Cat#PAB28591) at 4 ug/ml shows positivity in nucleus. -
Gene Info — APEX1
Entrez GeneID
328Protein Accession#
G3V3M6Gene Name
APEX1
Gene Alias
APE, APE-1, APE1, APEN, APEX, APX, HAP1, REF-1, REF1
Gene Description
APEX nuclease (multifunctional DNA repair enzyme) 1
Omim ID
107748Gene Ontology
HyperlinkGene Summary
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq
Other Designations
AP endonuclease class I|AP lyase|APEX nuclease|DNA-(apurinic or apyrimidinic site) lyase|OTTHUMP00000163988|apurinic/apyrimidinic (abasic) endonuclease|apurinic/apyrimidinic exonuclease|deoxyribonuclease (apurinic or apyrimidinic)|multifunctional DNA repa
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Interactome
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Pathway
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Disease
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