BIRC5 (phospho S20) polyclonal antibody (DyLight 650)
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of BIRC5.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S20 of human BIRC5.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen at ~16.5 kDa. In ICC/IF staining was observed in the spindle midzone, centrosome and intercellular bridge. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Form
Liquid
Conjugation
DyLight 650
Purification
Immunogen affinity purification
Recommend Usage
Immunocytochemistry/Immunofluorescence
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM sodium borate (0.05% sodium azide).
Storage Instruction
Store at 4°C in the dark.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
Immunofluorescence
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Gene Info — BIRC5
Entrez GeneID
332Protein Accession#
O15392Gene Name
BIRC5
Gene Alias
API4, EPR-1
Gene Description
baculoviral IAP repeat-containing 5
Omim ID
603352Gene Ontology
HyperlinkGene Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq
Other Designations
apoptosis inhibitor 4|baculoviral IAP repeat-containing protein 5|survivin variant 3 alpha
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