BAX polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of BAX in HL-60 cell lysates with BAX polyclonal antibody (Cat # PAB12927) at (A) 1, (B) 2, and (C) 4 ug/mL .
Immunocytochemistry
Immunocytochemistry staining of HL-60 cells using BAX polyclonal antibody (Cat # PAB12927) at 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BAX.
Immunogen
A synthetic peptide corresponding to N-terminus 16 amino acids of human BAX.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BAX in HL-60 cell lysates with BAX polyclonal antibody (Cat # PAB12927) at (A) 1, (B) 2, and (C) 4 ug/mL .Immunocytochemistry
Immunocytochemistry staining of HL-60 cells using BAX polyclonal antibody (Cat # PAB12927) at 2 ug/mL . -
Gene Info — BAX
Entrez GeneID
581Protein Accession#
AAA03619Gene Name
BAX
Gene Alias
BCL2L4
Gene Description
BCL2-associated X protein
Omim ID
600040Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq
Other Designations
apoptosis regulator BAX
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Interactome
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Pathway
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Disease
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Publication Reference
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The Bcl-2 protein family and its role in the development of neoplastic disease.
Heiser D, Labi V, Erlacher M, Villunger A.
Experimental Gerontology 2004 Aug; 39(8):1125.
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The Bcl-2 family: roles in cell survival and oncogenesis.
Cory S, Huang DC, Adams JM.
Oncogene 2003 Nov; 22(53):8590.
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Cell death in the third millennium.
Lockshin RA, Osborne B, Zakeri Z.
Cell Death and Differentiation 2000 Jan; 7(1):2.
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The Bcl-2 protein family and its role in the development of neoplastic disease.
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