FCGR3A monoclonal antibody, clone LNK16 (PE)
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against native FCGR3A.
Immunogen
Native purified FCGR3A from normal human peripheral blood granulocytes.
Host
Mouse
Reactivity
Human, Non-Human Primates
Specificity
This antibody reacts with CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA; 50-65 KDa; expressed on NK-cells, monocytes and macrophages) and CD16b (FcgammaRIIIB; 48 KDa; mainly expressed on neutrophils).
Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Immunoprecipitation
Flow Cytometry
Surface staining of human peripheral blood cells with FCGR3A monoclonal antibody, clone LNK16 (PE) (Cat # MAB4361). -
Gene Info — FCGR3A
Entrez GeneID
2214Gene Name
FCGR3A
Gene Alias
CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3
Gene Description
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Gene Ontology
HyperlinkGene Summary
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
Fc fragment of IgG, low affinity III, receptor for (CD16)|Fc fragment of IgG, low affinity IIIa, receptor for (CD16)|Fc gamma receptor III-A|Fc-gamma RIII-alpha|Fc-gamma RIIIa|Fc-gamma receptor III-2 (CD 16)|Fc-gamma receptor IIIb (CD16)|FcgammaRIIIA|OTTH
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Human macrophages kill human mesangial cells by Fas-L-induced apoptosis when triggered by antibody via CD16.
Boyle JJ.
Clinical and Experimental Immunology 2004 Sep; 137(3):529.
Application:Flow Cyt, Human, U-939.
-
IgE-mediated activation of NK cells through Fc gamma RIII.
Arase N, Arase H, Hirano S, Yokosuka T, Sakurai D, Saito T.
Journal of Immunology 2003 Mar; 170(6):3054.
-
The binding epitopes of human CD16 (Fc gamma RIII) monoclonal antibodies. Implications for ligand binding.
Tamm A, Schmidt RE.
Journal of Immunology 1996 Aug; 157(4):1576.
Application:Flow Cyt, Human, HEK 296 cells.
-
Human macrophages kill human mesangial cells by Fas-L-induced apoptosis when triggered by antibody via CD16.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com