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Flow Cytometry

Flow cytometry analysis of FAS (CD95) expression on the surface of various hematopoietic cell lines with purified FAS monoclonal antibody, clone LT95 (Cat # MAB0940) (detection by Goat anti - mouse IgG1 PE) . Histograms : Red, isotype mouse IgG1 control staining. Black, standard FAS monoclonal antibody, clone LT95 (Cat # MAB0940) . A : Jurkat human peripheral blood T cell leukemia cell line. B : RAMOS human Burkitt lymphoma cell line. C : CEM human leukemia cell line. D : MOLT - 4 human acute lymphoblastic T cell leukemia cell line.

Entrez GeneID

355

Gene Name

FAS

Gene Alias

ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6

Gene Description

Fas (TNF receptor superfamily, member 6)

Omim ID

134637 601859

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq

Other Designations

APO-1 cell surface antigen|CD95 antigen|Fas AMA|Fas antigen|OTTHUMP00000020045|OTTHUMP00000020046|OTTHUMP00000020051|OTTHUMP00000059646|apoptosis antigen 1|tumor necrosis factor receptor superfamily member 6|tumor necrosis factor receptor superfamily, mem