MMP2 (Human) ELISA Kit
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Specification
Product Description
MMP2 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human MMP2.
Suitable Sample
Cell Culture Supernatant, Plasma (Heparin), Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
625 to 40000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Quality Control Testing
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — MMP2
Entrez GeneID
4313Gene Name
MMP2
Gene Alias
CLG4, CLG4A, MMP-II, MONA, TBE-1
Gene Description
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
collagenase type IV-A|matrix metalloproteinase 2|matrix metalloproteinase-II|neutrophil gelatinase
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Interactome
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Pathway
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Disease
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Publication Reference
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Dextran-shelled oxygen-loaded nanodroplets reestablish a normoxia-like pro-angiogenic phenotype and behavior in hypoxic human dermal microvascular endothelium.
Basilico N, Magnetto C, D'Alessandro S, Panariti A, Rivolta I, Genova T, Khadjavi A, Gulino GR, Argenziano M, Soster M, Cavalli R, Giribaldi G, Guiot C, Prato M.
Toxicology and Applied Pharmacology 2015 Nov; 288(3):330.
Application:ELISA, Human, HMEC-1 cells.
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Intronic regulation of matrix metalloproteinase-2 revealed by in vivo transcriptional analysis in ischemia.
Lee JG, Dahi S, Mahimkar R, Tulloch NL, Alfonso-Jaume MA, Lovett DH, Sarkar R.
PNAS 2005 Nov; 102(45):16345.
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Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed.
Morgunova E, Tuuttila A, Bergmann U, Isupov M, Lindqvist Y, Schneider G, Tryggvason K.
Science 1999 Jun; 284(5420):1667.
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Completion of the primary structure of the human type IV collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16.
Huhtala P, Eddy RL, Fan YS, Byers MG, Shows TB, Tryggvason K.
Genomics 1990 Mar; 6(3):554.
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Dextran-shelled oxygen-loaded nanodroplets reestablish a normoxia-like pro-angiogenic phenotype and behavior in hypoxic human dermal microvascular endothelium.
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