QPRT polyclonal antibody (A01)
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More Files
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Western Blot (Cell lysate)
QPRT polyclonal antibody (A01), Lot # 060803QCS1 Western Blot analysis of QPRT expression in K-562 ( Cat # L009V1 ).
Western Blot detection against Immunogen (37.11 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant QPRT.
Immunogen
QPRT (NP_055113, 198 a.a. ~ 297 a.a) partial recombinant protein with GST tag.
Sequence
VEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (84); Rat (82)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.11 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
QPRT polyclonal antibody (A01), Lot # 060803QCS1 Western Blot analysis of QPRT expression in K-562 ( Cat # L009V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — QPRT
Entrez GeneID
23475GeneBank Accession#
NM_014298Protein Accession#
NP_055113Gene Name
QPRT
Gene Alias
QPRTase
Gene Description
quinolinate phosphoribosyltransferase
Omim ID
606248Gene Ontology
HyperlinkGene Summary
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq
Other Designations
nicotinate-nucleotide pyrophosphorylase (carboxylating)
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Interactome
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Pathway
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Publication Reference
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Characterization of the Kynurenine Pathway in Human Neurons.
Guillemin GJ, Cullen KM, Lim CK, Smythe GA, Garner B, Kapoor V, Takikawa O, Brew BJ.
Journal of Neuroscience 2007 Nov; 27(47):12884.
Application：IF, Human, Human neurons, SK-N-SH cells.
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Characterization of the Kynurenine Pathway in Human Neurons.
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