SNAI2 monoclonal antibody (M07), clone 2E10
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant SNAI2.
Immunogen
SNAI2 (NP_003059, 69 a.a. ~ 132 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
LPNGLSPLSGYSSSLGRVSPPPPSDTSSKDHSGSESPISDEEERLQSKLSDPHAIEAEKFQCN
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (32.78 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SNAI2 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — SNAI2
Entrez GeneID
6591GeneBank Accession#
NM_003068Protein Accession#
NP_003059Gene Name
SNAI2
Gene Alias
MGC10182, SLUG, SLUGH1, WS2D
Gene Description
snail homolog 2 (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq
Other Designations
OTTHUMP00000195093|neural crest transcription factor SLUG|slug (chicken homolog), zinc finger protein|slug homolog, zinc finger protein|snail 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Endoplasmic reticulum protein 29 regulates epithelial cell integrity during the mesenchymal-epithelial transition in breast cancer cells.
Bambang IF, Lee YK, Richardson DR, Zhang D.
Oncogene 2013 Mar; 32(10):1240.
Application:WB-Tr, Human, MDA-MB-231, BT549 cells.
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Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival.
Toyofuku T, Nojima S, Ishikawa T, Takamatsu H, Tsujimura T, Uemura A, Matsuda J, Seki T, Kumanogoh A.
Genes & Development 2012 Apr; 26(8):816.
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Endoplasmic reticulum protein 29 regulates epithelial cell integrity during the mesenchymal-epithelial transition in breast cancer cells.
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