MYC (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human MYC full-length ORF ( ENSP00000259523, 1 a.a. - 439 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
75.2
Interspecies Antigen Sequence
Mouse (91); Rat (90)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — MYC
Entrez GeneID
4609GeneBank Accession#
ENST00000259523Protein Accession#
ENSP00000259523Gene Name
MYC
Gene Alias
bHLHe39, c-Myc
Gene Description
v-myc myelocytomatosis viral oncogene homolog (avian)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
Other Designations
avian myelocytomatosis viral oncogene homolog|myc proto-oncogene protein|v-myc avian myelocytomatosis viral oncogene homolog
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Interactome
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Pathway
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Disease
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Publication Reference
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Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response.
Meng Xu, Ling Lin, Babul Moni Ram, Omprakash Shriwas, Kun-Han Chuang, Siyuan Dai, Kuo-Hui Su, Zijian Tang, Chengkai Dai.
Cell Reports 2023 May; 42(6):112557.
Application:Pull-Down, Recombinant proteins.
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Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.
Sang Bae Lee, Aram Ko, Young Taek Oh, Peiguo Shi, Fulvio D'Angelo, Brulinda Frangaj, Antonius Koller, Emily I Chen, Timothy Cardozo, Antonio Iavarone, Anna Lasorella.
Molecular Cell 2020 Aug; 79(3):376.
Application:WB, Human, U87 cells.
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Analysis of binding interfaces of the human scaffold protein AXIN1 by peptide microarrays.
Harnoš J, Ryneš J, Víšková P, Trantírková SF, Ešner LB, Trantírek L, Bryja V.
The Journal of Biological Chemistry 2018 Oct; 293(42):16337.
Application:Peptide array, Recombinant protein.
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NCYM promotes calpain-mediated Myc-nick production in human MYCN-amplified neuroblastoma cells.
Shoji W, Suenaga Y, Kaneko Y, Islam SM, Alagu J, Yokoi S, Nio M, Nakagawara A.
Biochemical and Biophysical Research Communications 2015 Jun; 461(3):501.
Application:WB, Human, Purified Protein.
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A matrix approach to guide IHC-based tissue biomarker development in oncology drug discovery.
Smith NR, Womack C.
The Journal of Pathology 2014 Jan; 232(2):190.
Application:WB, Recombinant protein.
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An Electrochemical Immunosensor based on gold nanoparticle tags for picomolar detection of c-Myc oncoprotein.
He JL, Tian YF, Cao Z, Zou W, Sun X.
Sensors and Actuators B: Chemical 2013 May; 181:835.
Application:EPair-Re, Human, Human serum.
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Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response.
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