HLA-DMA 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
HLA-DMA transfected lysate
Western Blot
Lane 1: HLA-DMA transfected lysate ( 29.2 KDa).
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-HLA-DMA full-length
Host
Human
Theoretical MW (kDa)
29.2
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-HLA-DMA antibody (H00003108-B01) by Western Blots.
SDS-PAGE Gel
HLA-DMA transfected lysate
Western Blot
Lane 1: HLA-DMA transfected lysate ( 29.2 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — HLA-DMA
Entrez GeneID
3108GeneBank Accession#
NM_006120Protein Accession#
NP_006111Gene Name
HLA-DMA
Gene Alias
D6S222E, DMA, HLADM, RING6
Gene Description
major histocompatibility complex, class II, DM alpha
Omim ID
142855Gene Ontology
HyperlinkGene Summary
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq
Other Designations
OTTHUMP00000029242|OTTHUMP00000062997|class II histocompatibility antigen, M alpha chain
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