DAZL polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DAZL.
Immunogen
A synthetic peptide corresponding to human DAZL.
Sequence
C-GNGPQKKSVDR
Host
Goat
Theoretical MW (kDa)
33.2
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western blot (0.1-0.3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
DAZL polyclonal antibody (Cat # PAB6834) (0.1 ug/mL) staining of human ovary lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
DAZL polyclonal antibody (Cat # PAB6834) staining of paraffin embedded mouse testis.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DAZL
Entrez GeneID
1618Protein Accession#
NP_001342.2Gene Name
DAZL
Gene Alias
DAZH, DAZL1, DAZLA, MGC26406, SPGYLA
Gene Description
deleted in azoospermia-like
Omim ID
601486Gene Ontology
HyperlinkGene Summary
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. [provided by RefSeq
Other Designations
deleted in azoospermia-like autosomal|germline specific RNA binding protein|spermatogenesis gene on the Y-like autosomal
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Interactome
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Disease
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Publication Reference
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DAZL expression in human oocytes, preimplantation embryos and embryonic stem cells.
Cauffman G, Van de Velde H, Liebaers I, Van Steirteghem A.
Molecular Human Reproduction 2005 Jun; 11(6):405.
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DAZL expression in human oocytes, preimplantation embryos and embryonic stem cells.
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