CAMK2D polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CAMK2D.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CAMK2D.
Host
Rabbit
Reactivity
Human, Monkey
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The CAMK2D polyclonal antibody (Cat # PAB2773) is used in Western blot to detect CAMK2D in serum-starved HeLa cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with CAMK2D polyclonal antibody (Cat # PAB2773) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — CAMK2D
Entrez GeneID
817Protein Accession#
NP_001212;Q13557Gene Name
CAMK2D
Gene Alias
CAMKD, DKFZp686G23119, DKFZp686I2288, MGC44911
Gene Description
calcium/calmodulin-dependent protein kinase II delta
Omim ID
607708Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns
Other Designations
CaM kinase II delta subunit|CaM-kinase II delta chain|CaMK-II delta subunit|OTTHUMP00000163829|OTTHUMP00000163830|calcium/calmodulin-dependent protein kinase (CaM kinase) II delta|calcium/calmodulin-dependent protein kinase type II delta chain
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Interactome
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Publication Reference
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Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.
Rochlitz H, Voigt A, Lankat-Buttgereit B, Goke B, Heimberg H, Nauck MA, Schiemann U, Schatz H, Pfeiffer AF.
Diabetologia 2000 Apr; 43(4):465.
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Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.
Hoch B, Meyer R, Hetzer R, Krause EG, Karczewski P.
Circulation Research 1999 Apr; 84(6):713.
Application:WB-Ti, Human, Human myocardium.
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Identification of novel human tumor cell-specific CaMK-II variants.
Tombes RM, Krystal GW.
Biochimica et Biophysica acta 1997 Mar; 1355(3):281.
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Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.
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