Western blot analysis of HIST1H3B (phospho S28) polyclonal antibody (Cat # PAB0484) in HepG2 cell line lysate (35 ug/lane). Mouse Phospho-HIST1H3B-pS28 (arrow) was detected using the purified polyclonal antibody (1 : 64 dilution).
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq
H3 histone family, member L,OTTHUMP00000016132,histone 1, H3b