BIRC5 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot
Western blot analysis of BIRC5. Using BIRC5 polyclonal antibody (Cat # PAB0272) at 1 : 2000. BIRC5 was detected in the two tumor cell lines, Jurkat (T cell lymphoma) and RS11846 (non-Hodgkin's lymphoma), but not in lysates from normal tissues. BIRC5 RP, full-length recombiant human BIRC5 protein was used as a positive control.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of BIRC5 in formalin-fixed, paraffin-embedded human prostate and breast cancer. Using BIRC5 polyclonal antibody (Cat # PAB0272) at 1 : 2000. A and A1, prostate cancer at low and high magnification, respectively. B and B1, breast cancer. B1 is a high magnification of an area of metastasis. Hematoxylin-eosin counterstain.
-
Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant BIRC5.
Immunogen
Recombinant protein corresponding to full length human BIRC5.
Host
Rabbit
Reactivity
Gerbils, Human, Mouse, Rat
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot
Western blot analysis of BIRC5. Using BIRC5 polyclonal antibody (Cat # PAB0272) at 1 : 2000. BIRC5 was detected in the two tumor cell lines, Jurkat (T cell lymphoma) and RS11846 (non-Hodgkin's lymphoma), but not in lysates from normal tissues. BIRC5 RP, full-length recombiant human BIRC5 protein was used as a positive control.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of BIRC5 in formalin-fixed, paraffin-embedded human prostate and breast cancer. Using BIRC5 polyclonal antibody (Cat # PAB0272) at 1 : 2000. A and A1, prostate cancer at low and high magnification, respectively. B and B1, breast cancer. B1 is a high magnification of an area of metastasis. Hematoxylin-eosin counterstain.Immunohistochemistry (Frozen sections)
Immunoprecipitation
-
Gene Info — BIRC5
Entrez GeneID
332Gene Name
BIRC5
Gene Alias
API4, EPR-1
Gene Description
baculoviral IAP repeat-containing 5
Omim ID
603352Gene Ontology
HyperlinkGene Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq
Other Designations
apoptosis inhibitor 4|baculoviral IAP repeat-containing protein 5|survivin variant 3 alpha
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
URH49 exports mRNA by remodeling complex formation and mediating the NXF1-dependent pathway.
Fujita KI, Yamazaki T, Harada K, Seno S, Matsuda H, Masuda S.
Biochimica et Biophysica Acta. Gene Regulatory Mechanisms 2020 Feb; 1863(2):194480.
Application：WB, Human, MCF-7 cells.
-
Survivin and heat shock protein 25/27 colocalize with cleaved caspase-3 in surviving reactive astrocytes following excitotoxicity to the immature brain.
Villapol S, Acarin L, Faiz M, Castellano B, Gonzalez B.
Neuroscience 2008 Feb; 153(1):108.
-
URH49 exports mRNA by remodeling complex formation and mediating the NXF1-dependent pathway.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com