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BIOtech
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ANPEP (Human) Native ProteinBioActive

  • Catalog # : P4918
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  • Specification
  • Product Description:
  • Human ANPEP (967 amino acids) native protein from human serum.
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 110-130
  • Form:
  • Liquid
  • Preparation Method:
  • Native protein purified from human serum
  • Purification:
  • Saltprecipitation/Ion Exchange Chromatography/Gelfiltration
  • Purity:
  • > 90% by SDS-PAGE
  • Activity:
  • > 500 mU/mg (L-Leu-pNA at 37°C, pH 7.2).
  • Quality Control Testing:
  • 15% SDS-PAGE Stained with Coomassie Blue

    QC Testing of P4918
  • Storage Buffer:
  • In 20 mM Tris-HCl, 500 mM NaCl, 1 mM CaCl2, pH 7.4
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 290
  • Gene Name:
  • ANPEP
  • Gene Alias:
  • APN,CD13,LAP1,PEPN,gp150,p150
  • Gene Description:
  • alanyl (membrane) aminopeptidase
  • Gene Summary:
  • Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000194690,aminopeptidase M,aminopeptidase N,membrane alanine aminopeptidase,microsomal aminopeptidase
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