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BIOtech
BULK-new

GHR monoclonal antibody, clone B767M

  • Catalog # : MAB6715
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against GHR.
  • Immunogen:
  • Human GHR conjugated with APP.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes Growth hormone receptor hormone complex and free Growth hormone receptor.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.1% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • ELISA
  • Application Image
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 2690
  • Gene Name:
  • GHR
  • Gene Alias:
  • GHBP
  • Gene Description:
  • growth hormone receptor
  • Gene Summary:
  • This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. The precise location of this cleavage site has not been determined for the human protein
  • Other Designations:
  • growth hormone binding protein,serum binding protein,somatotropin receptor
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