CD44 monoclonal antibody, clone DF 1485
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Specification
Product Description
Mouse monoclonal antibody raised against native CD44.
Immunogen
CD44 antigen (PGp-1) purified from lymphocyte membrane.
Host
Mouse
Reactivity
Human
Specificity
HCAM, CD44 is a transmembrane glycoprotein which is expressed by lymphocytes and several normal epithelial cells. The CD44 molecule is involved in lymphocyte homing, T-lymphocyte actvitation, interaction with hyaluronic acid and may act as an adhesion molecule. Standard CD 44 (CD44s) is composed of the products of exons 1-5 a less favourable prognosis in gastrointestinal cancers, the loss of CD44s expression predicts unfavourable outcome in bladder cancers, squamous cell carcinomas of the skin, prostatic adenocarcinomas and neuroblastomas. In immunoblotting this antibody reacts with a glycoprotein isolated from hemopoietic cells and epithelials cells with a respective molecular weight of 29-37 and 51 kD.
Form
Liquid
Isotype
IgG1
Recommend Usage
Immunohistochemistry (1:5-1:10)
The optimal working dilution should be determined by the end user.Storage Buffer
In antibody solution (0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
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Gene Info — CD44
Entrez GeneID
960Gene Name
CD44
Gene Alias
CDW44, CSPG8, ECMR-III, HCELL, IN, LHR, MC56, MDU2, MDU3, MGC10468, MIC4, MUTCH-I, Pgp1
Gene Description
CD44 molecule (Indian blood group)
Omim ID
107269Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq
Other Designations
CD44 antigen|CD44 antigen (homing function and Indian blood group system)|CDW44 antigen|GP90 lymphocyte homing/adhesion receptor|Hermes antigen|antigen gp90 homing receptor|cell adhesion molecule|cell surface glycoprotein CD44|chondroitin sulfate proteogl
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Interactome
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Pathway
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Disease
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Publication Reference
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Immunoexpression of claudins 4 and 7 among invasive breast carcinoma subtypes: A large diagnostic study using tissue microarray.
Logullo AF, Pasini FS, Nonogaki S, Rocha RM, Soares FA, Brentani MM.
Molecular and Clinical Oncology 2018 Oct; 9(4):377.
Application：IHC-P, Human, Human mammary invasive carcinomas.
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Immunoexpression of claudins 4 and 7 among invasive breast carcinoma subtypes: A large diagnostic study using tissue microarray.
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