CD14 monoclonal antibody, clone MEM-15 (Biotin)
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Specification
Product Description
Mouse monoclonal antibody raised against native CD14.
Immunogen
Native purified human CD14.
Host
Mouse
Theoretical MW (kDa)
53-55
Reactivity
Human, Primates
Specificity
This antibody reacts with CD14, a 53-55 KDa GPI (glycosylphosphatidylinositol)-linked membrane glycoprotein expressed on monocytes, macrophages and weakly on granulocytes; also expressed by most tissue macrophages. This antibody also reacts with soluble forms of CD14 found in serum and in the urine of some nephrotic patients.
Form
Liquid
Conjugation
Biotin
Isotype
IgG1
Recommend Usage
Flow Cytometry (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — CD14
Entrez GeneID
929Gene Name
CD14
Gene Alias
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Gene Description
CD14 molecule
Omim ID
158120Gene Ontology
HyperlinkGene Summary
CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq
Other Designations
CD14 antigen|monocyte differentiation antigen CD14
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Interactome
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Pathway
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Disease
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Publication Reference
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Soluble CD14 discriminates slight structural differences between lipid as that lead to distinct host cell activation.
Asai Y, Makimura Y, Kawabata A, Ogawa T.
Journal of Immunology 2007 Dec; 179(11):7674.
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Soluble CD14: role in atopic disease and recurrent infections, including otitis media.
Karin C Lodrup Carlsen, Berit Granum.
Current Allergy and Asthma Reports 2007 Nov; 7(6):436.
Application:ELISA, Flow Cyt, Human, Human amniotic fluid, Human breast milk, Human bronchoalveolar lavage, Human cerebrospinal fluid, Human serum, Human synovial fluid.
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Biochemical characterization of a soluble form of the 53-kDa monocyte surface antigen.
Bazil V, Horejsi V, Baudys M, Kristofova H, Strominger JL, Kostka W, Hilgert I.
European Journal of Immunology 1986 Dec; 16(12):1583.
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Soluble CD14 discriminates slight structural differences between lipid as that lead to distinct host cell activation.
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