FCGR3A monoclonal antibody, clone GRM1
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Specification
Product Description
Mouse monoclonal antibody raised against native FCGR3A.
Immunogen
Normal human peripheral blood granulocytes.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a
Recommend Usage
Flow Cytometry (20 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 1% BSA, pH 7.2 (0.09% sodium azide).
Storage Instruction
Store in the dark at 4°C. Avoid prolonged exposure to light.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Flow Cytometry
Flow Cytometry using human peripheral blood cells (1 ug/106 cells).
FACSCalibur (Becton Dickinson, San Jose, CA) flow cytometer, using Cell Quest acquisition software and PAINT-A-GATE. PRO, analysis software. -
Gene Info — FCGR3A
Entrez GeneID
2214Gene Name
FCGR3A
Gene Alias
CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3
Gene Description
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Gene Ontology
HyperlinkGene Summary
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
Fc fragment of IgG, low affinity III, receptor for (CD16)|Fc fragment of IgG, low affinity IIIa, receptor for (CD16)|Fc gamma receptor III-A|Fc-gamma RIII-alpha|Fc-gamma RIIIa|Fc-gamma receptor III-2 (CD 16)|Fc-gamma receptor IIIb (CD16)|FcgammaRIIIA|OTTH
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Interactome
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Pathway
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Disease
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Publication Reference
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Comparative analysis of the morphological, cytochemical, immunophenotypical, and functional characteristics of normal human peripheral blood lineage(-)/CD16(+)/HLA-DR(+)/CD14(-/lo) cells, CD14(+) monocytes, and CD16(-) dendritic cells.
Almeida J, Bueno C, Alguero MC, Sanchez ML, de Santiago M, Escribano L, Diaz-Agustin B, Vaquero JM, Laso FJ, San Miguel JF, Orfao A.
Clinical Immunology (Orlando, Fla.) 2001 Sep; 100(3):325.
Application:Flow Cyt, Human, Human peripheral blood.
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Peripheral natural killer cytotoxicity and CD56(pos)CD16(pos) cells increase during early pregnancy in women with a history of recurrent spontaneous abortion.
Emmer PM, Nelen WL, Steegers EA, Hendriks JC, Veerhoek M, Joosten I.
Human Reproduction (Oxford, England) 2000 May; 15(5):1163.
Application:Flow Cyt, Human, Human nature killer cells.
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Clinical progression of HIV infection: role of NK cells.
Bruunsgaard H, Pedersen C, Skinhoj P, Pedersen BK.
Scandinavian Journal of Immunology 1997 Jul; 46(1):91.
Application:Flow Cyt, Human, Human natural killer cells.
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Comparative analysis of the morphological, cytochemical, immunophenotypical, and functional characteristics of normal human peripheral blood lineage(-)/CD16(+)/HLA-DR(+)/CD14(-/lo) cells, CD14(+) monocytes, and CD16(-) dendritic cells.
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