CD14 monoclonal antibody, clone MEM-15
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Specification
Product Description
Mouse monoclonal antibody raised against full length native CD14.
Immunogen
Native purified human CD14.
Host
Mouse
Theoretical MW (kDa)
53-55
Reactivity
Human
Specificity
This antibody reacts with CD14, a 53-55 KDa GPI (glycosylphosphatidylinositol)-linked membrane glycoprotein expressed on monocytes, macrophages and weakly on granulocytes; also expressed by most tissue macrophages.
This antibody MEM-15 also reacts with soluble forms of CD14 found in serum and in the urine of some nephrotic patients.Form
Liquid
Purification
Protein A affinity chromatography
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunoprecipitation
Flow Cytometry
Surface staining of human peripheral blood cells with CD14 monoclonal antibody, clone MEM-15 (Cat # MAB3831) conjugated with PE. -
Gene Info — CD14
Entrez GeneID
929Gene Name
CD14
Gene Alias
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Gene Description
CD14 molecule
Omim ID
158120Gene Ontology
HyperlinkGene Summary
CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq
Other Designations
CD14 antigen|monocyte differentiation antigen CD14
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Interactome
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Pathway
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Disease
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Publication Reference
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Soluble CD14 discriminates slight structural differences between lipid as that lead to distinct host cell activation.
Asai Y, Makimura Y, Kawabata A, Ogawa T.
Journal of Immunology 2007 Dec; 179(11):7674.
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Soluble CD14: role in atopic disease and recurrent infections, including otitis media.
Karin C Lodrup Carlsen, Berit Granum.
Current Allergy and Asthma Reports 2007 Nov; 7(6):436.
Application:ELISA, Flow Cyt, Human, Human amniotic fluid, Human breast milk, Human bronchoalveolar lavage, Human cerebrospinal fluid, Human serum, Human synovial fluid.
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Biochemical characterization of a soluble form of the 53-kDa monocyte surface antigen.
Bazil V, Horejsi V, Baudys M, Kristofova H, Strominger JL, Kostka W, Hilgert I.
European Journal of Immunology 1986 Dec; 16(12):1583.
Application:WB, Antigen.
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Soluble CD14 discriminates slight structural differences between lipid as that lead to distinct host cell activation.
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