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BIOtech
BULK-new

ABCB1 monoclonal antibody, clone MRK16

  • Catalog # : MAB3345
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native ABCB1.
  • Immunogen:
  • Native purified ABCB1 from Adriamycin-resistant human myelogenous leukemia K-562/ADM cells.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Monoclonal antibody MRK16 recognizes a surface epitope of the 170 KDa human P-glycoprotein. This antibody reacts with human cortical adenomas but does not react with eochromocytoma, non-functioning cortical adenoma or myolipoma of the adrenal. Does not react with mouse.
  • Form:
  • Liquid
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • Immunoprecipitation (25 ug/mL-50 ug/mL)
    Immunohistochemistry (0.1-10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Immunohistochemistry
  • Immunoprecipitation
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry
  • Immunoprecipitation
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 5243
  • Gene Name:
  • ABCB1
  • Gene Alias:
  • ABC20,CD243,CLCS,GP170,MDR1,MGC163296,P-GP,PGY1
  • Gene Description:
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Gene Summary:
  • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq
  • Other Designations:
  • ATP-binding cassette, subfamily B, member 1,P glycoprotein 1,P-glycoprotein 1,colchicin sensitivity,doxorubicin resistance,multidrug resistance 1,multidrug resistance protein 1
  • Gene Pathway
  • Related Disease
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