Mouse monoclonal antibody raised against native ABCB1.
Native purified ABCB1 from Adriamycin-resistant human myelogenous leukemia K-562/ADM cells.
Monoclonal antibody MRK16 recognizes a surface epitope of the 170 KDa human P-glycoprotein. This antibody reacts with human cortical adenomas but does not react with eochromocytoma, non-functioning cortical adenoma or myolipoma of the adrenal. Does not react with mouse.
Immunoprecipitation (25 ug/mL-50 ug/mL) Immunohistochemistry (0.1-10 ug/mL) The optimal working dilution should be determined by the end user.
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq
ATP-binding cassette, subfamily B, member 1,P glycoprotein 1,P-glycoprotein 1,colchicin sensitivity,doxorubicin resistance,multidrug resistance 1,multidrug resistance protein 1