MMP2 monoclonal antibody, clone SB13a
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant MMP2.
Immunogen
Recombinant protein corresponding to human MMP2.
Host
Mouse
Reactivity
Human
Specificity
human MMP-2, Does not cross react to human MMP-1, MMP-3 or MMP-9.
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:3000-1:8000)
Immunohistochemistry (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP2
Entrez GeneID
4313Gene Name
MMP2
Gene Alias
CLG4, CLG4A, MMP-II, MONA, TBE-1
Gene Description
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
collagenase type IV-A|matrix metalloproteinase 2|matrix metalloproteinase-II|neutrophil gelatinase
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Interactome
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Pathway
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Disease
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Publication Reference
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Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression.
Faisal Khan KM, Laurie GW, McCaffrey TA, Falcone DJ.
The Journal of Biological Chemistry 2002 Apr; 277(16):13778.
Application:Incubated, Recombinant protein.
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Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5.
Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V.
Science 1997 Jul; 277(5323):225.
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Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme.
Knäuper V, Will H, López-Otin C, Smith B, Atkinson SJ, Stanton H, Hembry RM, Murphy G.
The Journal of Biological Chemistry 1996 Jul; 271(29):17124.
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Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression.
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