MYC monoclonal antibody, clone IMD-3
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of MYC.
Immunogen
A synthetic peptide corresponding to human MYC.
Host
Mouse
Theoretical MW (kDa)
62
Reactivity
Human
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG1
Recommend Usage
Western Blot (4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (8 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunocytochemistry
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Gene Info — MYC
Entrez GeneID
4609Gene Name
MYC
Gene Alias
bHLHe39, c-Myc
Gene Description
v-myc myelocytomatosis viral oncogene homolog (avian)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
Other Designations
avian myelocytomatosis viral oncogene homolog|myc proto-oncogene protein|v-myc avian myelocytomatosis viral oncogene homolog
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Interactome
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Pathway
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Disease
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Publication Reference
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Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse.
Huang CY, Bredemeyer AL, Walker LM, Bassing CH, Sleckman BP.
European Journal of Immunology 2008 Feb; 38(2):342.
Application:WB-Ce, Mouse, Mouse T cells.
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Downregulation of c-Myc determines sensitivity to 2-methoxyestradiol-induced apoptosis in human acute myeloid leukemia.
Chow JM, Liu CR, Lin CP, Lee CN, Cheng YC, Lin S, Liu HE.
Experimental Hematology 2008 Feb; 36(2):140.
Application:WB-Ce, Human, HL-60, NB4, U-937 cells.
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c-MYC protein is degraded in response to UV irradiation.
Britton S, Salles B, Calsou P.
Cell Cycle 2008 Jan; 7(1):63.
Application:WB-Tr, Human, U2OS cells.
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Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse.
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