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Last updated: 2015/5/31
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FAS monoclonal antibody, clone EOS9.1

  • Catalog # : MAB10854
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against FAS.
  • Immunogen:
  • Human FAS.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 40-50
  • Reactivity:
  • Human
  • Specificity:
  • The monoclonal antibody reacts with FAS, a 40-50 kDa member of the TNFR superfamily.
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgM, kappa
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In aqueous buffer (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Functional Study
  • Flow Cytometry
  • Flow Cytometry
  • The Jurkat cell line was treated for 6 hours with medium alone (upper) or 0.1 ug/mL of FAS monoclonal antibody, clone EOS9.1 (Cat # MAB10854) (bottom). Induction of apoptosis in these cells was determined by staining with Propidium Iodide and Anti-BrdU-FITC using the Apo-BrdU Apoptosis Detection Kit.
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 355
  • Gene Name:
  • FAS
  • Gene Alias:
  • ALPS1A,APO-1,APT1,CD95,FAS1,FASTM,TNFRSF6
  • Gene Description:
  • Fas (TNF receptor superfamily, member 6)
  • Gene Summary:
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq
  • Other Designations:
  • APO-1 cell surface antigen,CD95 antigen,Fas AMA,Fas antigen,OTTHUMP00000020045,OTTHUMP00000020046,OTTHUMP00000020051,OTTHUMP00000059646,apoptosis antigen 1,tumor necrosis factor receptor superfamily member 6,tumor necrosis factor receptor superfamily, mem
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