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BIOtech
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HLA-DR/HLA-DP monoclonal antibody, clone MEM-136

  • Catalog # : MAB0917
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native HLA-DR/HLA-DP.
  • Immunogen:
  • Native purified HLA-DR/HLA-DP from PHA-activated peripheral blood leucocytes.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes common epitope on beta-chain of human HLA-DR and HLA-DP. It reacts with alpha/beta dimer as well as with dissociated beta-subunit.
  • Form:
  • Liquid
  • Concentration:
  • 1 mg/mL
  • Isotype:
  • IgG1
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (15 mM sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blotting analysis of MHC Class II in whole cell lysate of Raji human Burkitt lymphoma cell line using HLA - DR/HLA - DP monoclonal antibody, clone MEM - 136 (Cat # MAB0917) . The HLA - DR/HLA - DP monoclonal antibody, clone MEM - 136 (Cat # MAB0917) under non - reducing conditions. Lane 1 : Immunostaining with HLA - DR/HLA - DP monoclonal antibody, clone MEM - 136 (Cat # MAB0917) . Lane 2 : Immunostaining with Isotype mouse IgG1 control.
  • Immunoprecipitation
  • Flow Cytometry
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunoprecipitation
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3115
  • Gene Name:
  • HLA-DPB1
  • Gene Alias:
  • DPB1,HLA-DP1B
  • Gene Description:
  • major histocompatibility complex, class II, DP beta 1
  • Gene Summary:
  • HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq
  • Other Designations:
  • HLA DP14-beta chain,HLA-DP histocompatibility type, beta-1 subunit,MHC HLA DPB1,MHC class II HLA-DP-beta,MHC class II HLA-DP-beta-1,MHC class II HLA-DRB1,MHC class II antigen DP beta 1 chain,MHC class II antigen DPbeta1,MHC class II antigen beta chain,OTT
  • Gene Information
  • Entrez GeneID:
  • 3123
  • Gene Name:
  • HLA-DRB1
  • Gene Alias:
  • DRB1,FLJ76359,HLA-DR1B,HLA-DRB,HLA-DRB1*,SS1
  • Gene Description:
  • major histocompatibility complex, class II, DR beta 1
  • Gene Summary:
  • HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq
  • Other Designations:
  • HLA class II antigen beta chain,HLA class II histocompatibility antigen, DR-1 beta chain,HLA-DR-beta 1,MHC class II HLA-DR beta 1 chain,MHC class II HLA-DR-beta cell surface glycoprotein,MHC class II antigen HLA-DR13,human leucocyte antigen DRB1,leucocyte
  • Gene Information
  • Entrez GeneID:
  • 3125
  • Gene Name:
  • HLA-DRB3
  • Gene Alias:
  • HLA-DR3B,MGC117330
  • Gene Description:
  • major histocompatibility complex, class II, DR beta 3
  • Gene Summary:
  • HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq
  • Other Designations:
  • MHC class II HLA-DR beta 3 chain,MHC class II antigen DR beta 3 chain,human leucocyte antigen DRB3
  • Gene Information
  • Entrez GeneID:
  • 3126
  • Gene Name:
  • HLA-DRB4
  • Gene Alias:
  • DRB4,HLA-DR4B
  • Gene Description:
  • major histocompatibility complex, class II, DR beta 4
  • Gene Summary:
  • HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq
  • Other Designations:
  • DRB1 transplantation antigen,HLA DRB1*1202,MHC HLA DR-beta chain,MHC class II HLA-DR-beta-7,MHC class II antigen HLA-DR-beta,MHC class II antigen HLA-DRB1,MHC class2 antigen,class II histocompatibility antigen HLA DR alpha, beta1-0307,human leucocyte anti
  • Gene Information
  • Entrez GeneID:
  • 3127
  • Gene Name:
  • HLA-DRB5
  • Gene Alias:
  • -
  • Gene Description:
  • major histocompatibility complex, class II, DR beta 5
  • Gene Summary:
  • HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq
  • Other Designations:
  • HLA class II histocompatibility antigen, DR-5 beta chain,MHC HLA-DR-beta cell surface glycoprotein,MHC HLA-DR-beta chain,MHC class II HLA beta chain,MHC class II antigen,OTTHUMP00000029035,human leucocyte antigen DRB5,leukocyte antigen class II
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