SEMA4A (Human) Recombinant Protein (P01)
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Specification
Product Description
Human SEMA4A full-length ORF ( NP_071762.2, 1 a.a. - 761 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MALPALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSCSVGPSSDKALTFMKDHFLMDEQVVGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWSHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPVISYWVDSQDQTLALDPELAGIPREHVKVPLTRVSGGAALAAQQSYWPHFVTVTVLFALVLSGALIILVASPLRALRARGKVQGCETLRPGEKAPLSREQHLQSPKECRTSASDVDADNNCLGTEVA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
110
Interspecies Antigen Sequence
Mouse (83); Rat (83)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — SEMA4A
Entrez GeneID
64218GeneBank Accession#
NM_022367.2Protein Accession#
NP_071762.2Gene Name
SEMA4A
Gene Alias
CORD10, FLJ12287, RP35, SEMAB, SEMB
Gene Description
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Gene Ontology
HyperlinkGene Summary
SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM
Other Designations
OTTHUMP00000015916|OTTHUMP00000015917|OTTHUMP00000015918|sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4A|semaphorin B
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Interactome
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Pathway
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Disease
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Publication Reference
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Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1.
Chapoval SP, Hritzo M, Qi X, Tamagnone L, Golding A, Keegan AD.
ImmunoHorizons 2019 Feb; 3(2):71.
Application：Func, Human, HuT78, HuT102 cells.
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Expression of Semaphorin 4A and its potential role in rheumatoid arthritis.
Wang L, Song G, Zheng Y, Tan W, Pan J, Zhao Y, Chang X.
Arthritis Research & Therapy 2015 Aug; 17:227.
Application：Func, Human, Synovial fibroblasts of rheumatoid arthritis.
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Neuroimmune semaphorin 4A as a drug and drug target for asthma.
Mogie G, Shanks K, Nkyimbeng-Takwi EH, Smith E, Davila E, Lipsky MM, Detolla LJ, Keegan AD, Chapoval SP.
International Immunopharmacology 2013 Nov; 17(3):568.
Application：Injection, Recombinant protein.
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Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1.
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