BMP2 monoclonal antibody (M04), clone 3G7
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant BMP2.
Immunogen
BMP2 (NP_001191, 283 a.a. ~ 396 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged BMP2 is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — BMP2
Entrez GeneID
650GeneBank Accession#
NM_001200Protein Accession#
NP_001191Gene Name
BMP2
Gene Alias
BMP2A
Gene Description
bone morphogenetic protein 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq
Other Designations
OTTHUMP00000030228
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Interactome
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Pathway
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Disease
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Publication Reference
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BMP2 immune complexes promote new bone formation by facilitating the direct contact between osteoclasts and osteoblasts.
Yamei Xu, Yao Yang, Ziyi Hua, Shuang Li, Zhenyu Yang, Qianzi Liu, Gang Fu, Ping Ji, Qingqing Wu.
Biomaterials 2021 Aug; 275:120890.
Application:Func, Human, Mouse, Alginate microbeads, Human bone marrow-derived mesenchymal stem cells, Mouse orthotopic bone formation model.
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The sialylation profile of IgG determines the efficiency of antibody directed osteogenic differentiation of iMSCs by modulating local immune responses and osteoclastogenesis.
Qingqing Wu, Yao Yang, Dongni Xie, Shuang Li, Yunfei Liu, Linjing Shu, Gang Fu, Yamei Xu, Ping Ji.
Acta Biomaterialia 2020 Sep; 114:221.
Application:Conjugation, Flow Cyt, Func, IF, Human, Human induced pluripotent stem cell derived mesenchymal stem cells.
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Bacterial cellulose membrane functionalized with hydroxiapatite and anti-bone morphogenetic protein 2: A promising material for bone regeneration.
Coelho F, Cavicchioli M, Specian SS, Scarel-Caminaga RM, Penteado LA, Medeiros AI, Ribeiro SJL, Capote TSO.
PLoS One 2019 Aug; 14(8):e0221286.
Application:IF, Mouse, MC3T3-E1 cells.
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Therapeutic antibody directed osteogenic differentiation of Induced pluripotent stem cells derived MSCs.
Wu Q, Yang B, Cao C, Hu K, Wang P, Man Y.
Acta Biomaterialia 2018 Jul; 74:222.
Application:ELISA, Human, Supernatants collected from iPSC-derived mesenchymal stromal cells.
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Biomechanical analysis of engineered bone with anti-BMP2 antibody immobilized on different scaffolds.
Ansari S, Phark JH, Duarte S Jr, Paulino da Silva M, Sharifzadeh N, Moshaverinia A, Zadeh HH.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials 2016 Oct; 104(7):1465.
Application:IHC, Rat, Rat calvaria.
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Immobilization of Murine Anti-BMP-2 Monoclonal Antibody on Various Biomaterials for Bone Tissue Engineering.
Ansari S, Freire MO, Pang EK, Abdelhamid AI, Almohaimeed M, Zadeh HH.
BioMed Research International 2014 Jul; 2014:940860.
Application:IF, IHC, EM, Rat, Calvarial bone.
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Functionalization of scaffolds with chimeric anti-BMP-2 monoclonal antibodies for osseous regeneration.
Ansari S, Moshaverinia A, Pi SH, Han A, Abdelhamid AI, Zadeh HH.
Biomaterials 2013 Dec; 34(38):10191.
Application:Flow Cyt, IF, Mouse, C2C12 cells.
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Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in alginate microspheres for bone tissue engineering.
Moshaverinia A, Ansari S, Chen C, Xu X, Akiyama K, Snead ML, Zadeh HH, Shi S.
Biomaterials 2013 Sep; 34(28):6572.
Application:Flow Cyt, IF, Human, hBMMSCs.
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Antibody-mediated osseous regeneration: the early events in the healing response.
Freire MO, Kim HK, Kook JK, Nguyen A, Zadeh HH.
Tissue Engineering. Part A 2013 May; 19(9-10):1165.
Application:IF, Rat, Calvarial.
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Antibody-mediated osseous regeneration: a novel strategy for bioengineering bone by immobilized anti-bone morphogenetic protein-2 antibodies.
Freire MO, You HK, Kook JK, Choi JH, Zadeh HH.
Tissue Engineering. Part A 2011 Dec; 17(23-24):2911.
Application:Flow Cyt, Func, IHC, Mouse, Rat, C2C12 cells, Calvaria.
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BMP2 immune complexes promote new bone formation by facilitating the direct contact between osteoclasts and osteoblasts.
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