BAX monoclonal antibody (M01), clone 1F5-1B7
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to BAX on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between BCL2L1 and BAX. HeLa cells were stained with anti-BCL2L1 rabbit purified polyclonal 1:1200 and anti-BAX mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
Immunofluorescence
Immunofluorescence of monoclonal antibody to BAX on HeLa cell . [antibody concentration 10 ug/ml]
Western Blot detection against Immunogen (46.86 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant BAX.
Immunogen
BAX (AAH14175, 1 a.a. ~ 192 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTATIFVAGVLTASLTIWKKMG
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (46.86 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to BAX on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]ELISA
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between BCL2L1 and BAX. HeLa cells were stained with anti-BCL2L1 rabbit purified polyclonal 1:1200 and anti-BAX mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).Immunofluorescence
Immunofluorescence of monoclonal antibody to BAX on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — BAX
Entrez GeneID
581GeneBank Accession#
BC014175Protein Accession#
AAH14175Gene Name
BAX
Gene Alias
BCL2L4
Gene Description
BCL2-associated X protein
Omim ID
600040Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq
Other Designations
apoptosis regulator BAX
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Interactome
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Pathway
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Disease
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Publication Reference
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Long-term NaHS administration reduces oxidative stress and apoptosis in a rat model of left-side varicocele.
Lorian K, Kadkhodaee M, Kianian F, Abdi A, Ranjbaran M, Ashabi G, Seifi B.
Andrologia 2020 Mar; 52(2):e13496.
Application：WB-Ti, Rat, Rat testes.
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p53 is positively regulated by miR-542-3p.
Wang Y, Huang JW, Castella M, Huntsman DG, Taniguchi T.
Cancer Research 2014 Jun; 74(12):3218.
Application：WB-Tr, Human, HCT116 cells.
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Long-term NaHS administration reduces oxidative stress and apoptosis in a rat model of left-side varicocele.
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