AXL/CEN19q FISH Probe
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human hepatocellular carcinoma (FFPE) stained with AXL/CEN19q FISH Probe. Human hepatocellular carcinoma showed no AXL gene amplification.
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human lung adenocarcinoma (FFPE) stained with AXL/CEN19q FISH Probe. Human lung adenocarcinoma showed no AXL gene amplification.
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human breast cancer (FFPE) stained with AXL/CEN19q FISH Probe. Human breast cancer showed no AXL gene amplification.
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: AXL
Size: Approximately 290kb
Fluorophore: TexRed
Location: 19q13.2Probe 2
Name: CEN19q
Size: Approximately 430kb
Fluorophore: FITC
Location: 19q12Probe Gap
The gap between two probes is approximately 11000 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human hepatocellular carcinoma (FFPE) stained with AXL/CEN19q FISH Probe. Human hepatocellular carcinoma showed no AXL gene amplification.Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human lung adenocarcinoma (FFPE) stained with AXL/CEN19q FISH Probe. Human lung adenocarcinoma showed no AXL gene amplification.Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human breast cancer (FFPE) stained with AXL/CEN19q FISH Probe. Human breast cancer showed no AXL gene amplification. -
Gene Info — AXL
Entrez GeneID
558Gene Name
AXL
Gene Alias
JTK11, UFO
Gene Description
AXL receptor tyrosine kinase
Omim ID
109135Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
AXL transforming sequence/gene|oncogene AXL
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Interactome
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Disease
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Publication Reference
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AXL and MET Tyrosine Kinase Receptors Co-Expression as a Potential Therapeutic Target in Malignant Pleural Mesothelioma.
Federica Zito Marino, Carminia Maria Della Corte, Vincenza Ciaramella, Stefania Erra, Andrea Ronchi, Alfonso Fiorelli, Giovanni Vicidomini, Mario Santini, Giosuè Scognamiglio, Floriana Morgillo, Fortunato Ciardiello, Renato Franco, Marina Accardo.
Journal of Personalized Medicine 2022 Dec; 12(12):1993.
Application：FISH, Human, Human mesothelioma.
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AXL Is a Novel Predictive Factor and Therapeutic Target for Radioactive Iodine Refractory Thyroid Cancer.
Collina F, La Sala L, Liotti F, Prevete N, La Mantia E, Chiofalo MG, Aquino G, Arenare L, Cantile M, Liguori G, Di Gennaro F, Pezzullo L, Losito NS, Vecchio G, Botti G, Melillo RM, Franco R.
Cancers 2019 Jun; 11(6):E785.
Application：FISH-P, Human, Human thyroid cancer samples.
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AXL and MET Tyrosine Kinase Receptors Co-Expression as a Potential Therapeutic Target in Malignant Pleural Mesothelioma.
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