SOX2/CEN3q FISH Probe
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Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: SOX2
Size: Approximately 380kb
Fluorophore: Texas Red
Location: 3q26.3-q27Probe 2
Name: CEN3q
Size: Approximately 500kb
Fluorophore: FITC
Location: 3q12.1Probe Gap
The gap between two probes is approximately 85,400 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
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Gene Info — SOX2
Entrez GeneID
6657Gene Name
SOX2
Gene Alias
ANOP3, MCOPS3, MGC2413
Gene Description
SRY (sex determining region Y)-box 2
Gene Ontology
HyperlinkGene Summary
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq
Other Designations
SRY-related HMG-box gene 2|sex-determining region Y-box 2|transcription factor SOX2
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Interactome
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Disease
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