产品

Immunohistochemistry (Frozen sections)

Immunohistochemistry

Flow Cytometry

Mass Cytometry

Entrez GeneID

Gene Name

GP1BA

Gene Alias

BSS, CD42B, CD42b-alpha, GP1B, MGC34595

Gene Description

glycoprotein Ib (platelet), alpha polypeptide

Omim ID

Gene Ontology

Gene Summary

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq

Other Designations

platelet glycoprotein Ib alpha polypeptide|platelet membrane glycoprotein 1b-alpha subunit