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COVID-19 Humanized Monoclonal Antibody

In order to address the severity of SARS-CoV-2 pandemic, we have produced a humanized monoclonal antibody (7F7) neutralizing SARS-CoV-2 by spike protein immunization, mouse splenic fusion, hybridoma screening, and antibody humanization by CDR grafting. This 7F7 neutralizing antibody is further characterized by receptor-binding inhibition, neutralization, and antibody kinetic assays. The antibody is epitope mapped against spike domain proteins for antigen specificity. The Fc region of the antibody is mutated to minimize antibody-dependent enhancement (ADE) immune response.

 
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