CYP1B1 recombinant monoclonal antibody, clone R02-5A3
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CYP1B1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human CYP1B1.
Theoretical MW (kDa)
Calculated MW: 61 kD
Reactivity
Human, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at -20 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of rat brain lysates with CYP1B1 recombinant monoclonal antibody, clone R02-5A3 (Cat # RAB02345).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with CYP1B1 recombinant monoclonal antibody, clone R02-5A3 (Cat # RAB02345). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. -
Gene Info — CYP1B1
Entrez GeneID
1545Protein Accession#
Q16678Gene Name
CYP1B1
Gene Alias
CP1B, GLC3A, P4501B1
Gene Description
cytochrome P450, family 1, subfamily B, polypeptide 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq
Other Designations
aryl hydrocarbon hydroxylase|cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
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Interactome
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Pathway
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Disease
- Abortion
- Adenocarcinoma
- Adenoma
- Asperger Syndrome
- Asthma
- Atherosclerosis
- Autistic Disorder
- Brain Neoplasms
- Breast cancer
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