CYP17A1 recombinant monoclonal antibody, clone R08-2J5
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: K562, Lane 2: C6 and Lane 3: 3T3 lysates with CYP17A1 recombinant monoclonal antibody, clone R08-2J5 (Cat # RAB02341).
Immunocytochemistry
Immunocytochemical staining of Hela with CYP17A1 recombinant monoclonal antibody, clone R08-2J5 (Cat # RAB02341). (A) CYP17A1 (green) and (B) DAPI (blue).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CYP17A1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human CYP17A1.
Theoretical MW (kDa)
Calculated MW: 57 kD
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:100)
Immunoprecipitation (1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at -20 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: K562, Lane 2: C6 and Lane 3: 3T3 lysates with CYP17A1 recombinant monoclonal antibody, clone R08-2J5 (Cat # RAB02341).Immunohistochemistry
Immunocytochemistry
Immunocytochemical staining of Hela with CYP17A1 recombinant monoclonal antibody, clone R08-2J5 (Cat # RAB02341). (A) CYP17A1 (green) and (B) DAPI (blue).Immunofluorescence
Immunoprecipitation
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Gene Info — CYP17A1
Entrez GeneID
1586Protein Accession#
P05093Gene Name
CYP17A1
Gene Alias
CPT7, CYP17, P450C17, S17AH
Gene Description
cytochrome P450, family 17, subfamily A, polypeptide 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq
Other Designations
OTTHUMP00000020382|cytochrome P450, family 17|cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia|cytochrome p450 XVIIA1|steroid 17-alpha-hydroxylase/17,20 lyase|steroid 17-alpha-monooxygenase
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Interactome
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Pathway
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Disease
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