NUDT1 recombinant monoclonal antibody, clone R06-2K9
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: K562 and Lane 2: Hela lysates with NUDT1 recombinant monoclonal antibody, clone R06-2K9 (Cat # RAB02091).
Immunocytochemistry
Immunocytochemical staining of Hela with NUDT1 recombinant monoclonal antibody, clone R06-2K9 (Cat # RAB02091). (A) NUDT1 (green) and (B) DAPI (blue).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human NUDT1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human NUDT1.
Theoretical MW (kDa)
Calculated MW: 18 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry
Immunofluorescence(1:50-1:200)
Immunoprecipitation(1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at -20 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: K562 and Lane 2: Hela lysates with NUDT1 recombinant monoclonal antibody, clone R06-2K9 (Cat # RAB02091).Immunocytochemistry
Immunocytochemical staining of Hela with NUDT1 recombinant monoclonal antibody, clone R06-2K9 (Cat # RAB02091). (A) NUDT1 (green) and (B) DAPI (blue).Immunofluorescence
Immunoprecipitation
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Gene Info — NUDT1
Entrez GeneID
4521Protein Accession#
P36639Gene Name
NUDT1
Gene Alias
MTH1
Gene Description
nudix (nucleoside diphosphate linked moiety X)-type motif 1
Omim ID
600312Gene Ontology
HyperlinkGene Summary
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq
Other Designations
7,8-dihydro-8-oxoguanine triphosphatase|8-oxo-7,8-dihydrodeoxyguanosine triphosphatase|8-oxo-7,8-dihydroguanosine triphosphatase|8-oxo-dGTPase|OTTHUMP00000024690|OTTHUMP00000115537|OTTHUMP00000115538|OTTHUMP00000115539|OTTHUMP00000115540|mutT human homolo
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Interactome
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Disease
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