RPSA recombinant monoclonal antibody, clone R01-1D4
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against synthetic peptide of human 67kDa Laminin Receptor.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human 67kDa Laminin Receptor
Theoretical MW (kDa)
Calculated MW: 33 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunoprecipitation(1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of 67kDa Laminin Receptor in K562, C6, 3T3, Hela lysates using human 67kDa Laminin Receptor recombinant monoclonal antibody, clone R01-1D4 (Cat # RAB01637).Immunoprecipitation
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Gene Info — RPSA
Entrez GeneID
3921Protein Accession#
P08865Gene Name
RPSA
Gene Alias
37LRP, 67LR, LAMBR, LAMR1, LRP, p40
Gene Description
ribosomal protein SA
Omim ID
150370Gene Ontology
HyperlinkGene Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
67kD, ribosomal protein SA|laminin receptor 1 (67kD, ribosomal protein SA)
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Interactome
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Pathway
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