GTPBP4 recombinant monoclonal antibody, clone R07-8G0
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human GTPBP4.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human GTPBP4.
Theoretical MW (kDa)
Calculated MW: 74 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine, pH 7.4, (0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of GTPBP4/NOG1 in A549, HL-60 lysates using GTPBP4 antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded Human tonsil using GTPBP4/NOG1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Immunoprecipitation
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Gene Info — GTPBP4
Entrez GeneID
23560Protein Accession#
Q9BZE4Gene Name
GTPBP4
Gene Alias
CRFG, FLJ10686, FLJ10690, FLJ39774, NGB, NOG1
Gene Description
GTP binding protein 4
Gene Ontology
HyperlinkGene Summary
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq
Other Designations
G protein-binding protein CRFG|GTP-binding protein|chronic renal failure
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Interactome
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Disease
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