CD40 humanized monoclonal antibody, clone 6EOG
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of human CRC CD3 T cells were treated with CD40 Humanized monoclonal antibody, clone 6EOG (Cat # RAB01124-M01J)to activated human CD3 T cells.
Western Blot (Cell lysate)
CD40 Humanized monoclonal antibody, clone 6EOG. Western Blot analysis of CD40 expression in B-LCL.
Western Blot detection against Immunogen.
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Specification
Product Description
Humanized recombinant monoclonal antibody raised against CD40.
Antibody Species
Human
Immunogen
Human CD40 recombinant protein
Reactivity
Human
Form
Liquid
Purification
Protein A sepharose
Isotype
Human IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen.
Storage Buffer
In PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Flow Cytometry
Flow cytometric analysis of human CRC CD3 T cells were treated with CD40 Humanized monoclonal antibody, clone 6EOG (Cat # RAB01124-M01J)to activated human CD3 T cells.Western Blot (Cell lysate)
CD40 Humanized monoclonal antibody, clone 6EOG. Western Blot analysis of CD40 expression in B-LCL.Western Blot (Recombinant protein)
ELISA
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Gene Info — CD40
Entrez GeneID
958Gene Name
CD40
Gene Alias
Bp50, CDW40, MGC9013, TNFRSF5, p50
Gene Description
CD40 molecule, TNF receptor superfamily member 5
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
B cell surface antigen CD40|B cell-associated molecule|CD40 antigen|CD40 antigen (TNF receptor superfamily member 5)|CD40 type II isoform|CD40L receptor|OTTHUMP00000031699|OTTHUMP00000031700|nerve growth factor receptor-related B-lymphocyte activation mol
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Interactome
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Pathway
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Disease
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