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Immunofluorescence

Immunofluoresence staining of fixed HeLa cells with NOTCH2 monoclonal antibody, clone B6 (Cat # RAB01086).
Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton stained with the chimeric rabbit antibody (Cat # RAB01086) at 10 ug/mL for 1h followed by Alexa Fluor®488 secondary antibody (1 ug/mL), showing membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom Cat # RAB01086, DAPI, merged channels and a negative control. The negative control was stained with unimmunized rabbit IgG followed by Alexa Fluor®488 secondary antibody.

Entrez GeneID

4853

Protein Accession#

Q04721|O35516

Gene Name

NOTCH2

Gene Alias

AGS2, hN2

Gene Description

Notch homolog 2 (Drosophila)

Omim ID

600275 610205

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. [provided by RefSeq

Other Designations

OTTHUMP00000014035|OTTHUMP00000059536|notch 2

Entrez GeneID

18129

Protein Accession#

Q04721|O35516

Gene Name

Notch2

Gene Alias

AI853703, N2

Gene Description

Notch gene homolog 2 (Drosophila)

Gene Ontology

Hyperlink

Other Designations

Motch B|Notch gene homolog 2