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NOTCH1 monoclonal antibody, clone E6 

  • Catalog # : RAB01083
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  • Specification
  • Product Description:
  • Recombinant mouse monoclonal antibody raised against NOTCH1.
  • Immunogen:
  • This antibody was selected against a fusion protein consisting of EGF domains 1–12 of murine Notch1 fused to a human Fc domain and binds to to the NRR of mouse Notch1.
  • Host:
  • Mouse
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • This engineered ScFv fragment antibody reacts to both mouse mNRR1 and human hNRR1 but not NRR2.
  • Form:
  • Liquid
  • Purification:
  • Protein A affinity purified
  • Isotype:
  • Mouse IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry
    Immunofluorescence
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% Proclin 300)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 4851
  • Gene Name:
  • NOTCH1
  • Gene Alias:
  • TAN1,hN1
  • Gene Description:
  • Notch homolog 1, translocation-associated (Drosophila)
  • Gene Summary:
  • This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000022594,neurogenic locus notch homolog protein 1,notch1,translocation-associated notch protein TAN-1
  • Gene Information
  • Gene Name:
  • Notch1
  • Gene Alias:
  • 9930111A19Rik,Mis6,Tan1,lin-12
  • Gene Description:
  • Notch gene homolog 1 (Drosophila)
  • Other Designations:
  • Notch 1,OTTMUSP00000013754,major type A protein,transmembrane receptor Notch1
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