CDH1 recombinant monoclonal antibody, clone CDH1/2208R
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot (cell lysate) analysis of MCF-7 cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon carcinoma.
Immunofluorescence
Immunofluorescence staining of MCF-7 cells. This antibody followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).
Flow Cytometry
Flow cytometric analysis of MCF-7 cells. This antibody followed by goat anti-mouse IgG-CF488 (Blue). Isotype Control (Red).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against full length human CDH1.
Antibody Species
Rabbit
Immunogen
Recombinant protein corresponding to full-length human CDH1.
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG
Recommend Usage
Flow Cytometry (1-2 ug/million cells)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Immunofluorescence (1-2 ug/mL)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 1 mg/mL PBS
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western Blot (cell lysate) analysis of MCF-7 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon carcinoma.Immunofluorescence
Immunofluorescence staining of MCF-7 cells. This antibody followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).Flow Cytometry
Flow cytometric analysis of MCF-7 cells. This antibody followed by goat anti-mouse IgG-CF488 (Blue). Isotype Control (Red). -
Gene Info — CDH1
Entrez GeneID
999Protein Accession#
P12830Gene Name
CDH1
Gene Alias
Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Gene Description
cadherin 1, type 1, E-cadherin (epithelial)
Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq
Other Designations
cadherin 1, E-cadherin (epithelial)|cadherin 1, type 1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|uvomorulin
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Interactome
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Pathway
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Disease
- Adenocarcinoma
- Asthma
- Breast cancer
- Breast Neoplasms
- Bronchiolitis
- Carcinoma
- Cleft Lip
- Cleft Palate
- Colitis
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