CD86 recombinant monoclonal antibody, clone C86/2160R
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Specifications
Product Description
Rabbit recombinant monoclonal antibody raised against full length human CD86.
Antibody Species
Rabbit
Immunogen
Recombinant protein corresponding to full-length human CD86.
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG
Recommend Usage
ELISA (2-4 ug/mL for coating)
Flow Cytometry (1-2 ug/million cells)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Immunofluorescence (1-2 ug/mL)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 1 mg/mL PBS
Storage Instruction
Store at -20 to -80°C.
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Applications
Western Blot (Cell lysate)
Western Blot (cell lysate) analysis of Ramos cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon.Immunofluorescence
Immunofluorescence staining of Raji cells. Goat anti-rabbit IgG conjugated to CF488 (Green) ; Nuclei are stained with Reddot.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Flow cytometric analysis of Ramos cells. This antibody followed by goat anti-mouse IgG-CF488 (Blue). Isotype Control (Red). -
Gene Info — CD86
Entrez GeneID
942Protein Accession#
P4208Gene Name
CD86
Gene Alias
B7-2, B70, CD28LG2, LAB72, MGC34413
Gene Description
CD86 molecule
Omim ID
601020Gene Ontology
HyperlinkGene Summary
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq
Other Designations
B-lymphocyte activation antigen B7-2|B7-2 antigen|CD28 antigen ligand 2|CD86 antigen|CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)|CTLA-4 counter-receptor B7.2
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Interactomes
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Pathways
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Diseases
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