Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Entrez GeneID

Protein Accession#

Gene Name

BCL6

Gene Alias

BCL5, BCL6A, LAZ3, ZBTB27, ZNF51

Gene Description

B-cell CLL/lymphoma 6

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq

Other Designations

B-cell lymphoma 6 protein|B-cell lymphoma 6 protein transcript|cys-his2 zinc finger transcription factor|lymphoma-associated zinc finger gene on chromosome 3|zinc finger protein 51|zinc finger transcription factor BCL6S