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Entrez GeneID

Protein Accession#

Gene Name

HLA-DPB1

Gene Alias

DPB1, HLA-DP1B

Gene Description

major histocompatibility complex, class II, DP beta 1

Omim ID

Gene Ontology

Gene Summary

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq

Other Designations

HLA DP14-beta chain|HLA-DP histocompatibility type, beta-1 subunit|MHC HLA DPB1|MHC class II HLA-DP-beta|MHC class II HLA-DP-beta-1|MHC class II HLA-DRB1|MHC class II antigen DP beta 1 chain|MHC class II antigen DPbeta1|MHC class II antigen beta chain|OTT