CD1A recombinant monoclonal antibody, clone C1A/1506R
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with CD1A recombinant monoclonal antibody, clone C1A/1506R (Cat # RAB00362).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CD1A.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human CD1A.
Theoretical MW (kDa)
49
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with CD1A recombinant monoclonal antibody, clone C1A/1506R (Cat # RAB00362).Immunofluorescence
Flow Cytometry
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Gene Info — CD1A
Entrez GeneID
909Protein Accession#
P06126Gene Name
CD1A
Gene Alias
CD1, FCB6, HTA1, R4, T6
Gene Description
CD1a molecule
Omim ID
188370Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq
Other Designations
CD1A antigen|CD1A antigen, a polypeptide|OTTHUMP00000018907|T-cell surface antigen T6/Leu-6|T-cell surface glycoprotein CD1a|cluster of differentiation 1 A|cortical thymocyte antigen CD1A|differentiation antigen CD1-alpha-3|epidermal dendritic cell marker
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Interactome
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Pathway
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Disease
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Publication Reference
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Foreign body-type multinucleated giant cells induced by interleukin-4 express select lymphocyte co-stimulatory molecules and are phenotypically distinct from osteoclasts and dendritic cells.
McNally AK, Anderson JM.
Experimental and Molecular Pathology 2011 Dec; 91(3):673.
Application：WB-Ce, Human, Dendritic cells, HEK 293T cells, Monocytes.
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Hyperexpression of the high-affinity IgE receptor-beta chain in chronic allergic keratoconjunctivitis.
Matsuda A, Okayama Y, Ebihara N, Yokoi N, Hamuro J, Walls AF, Ra C, Hopkin JM, Kinoshita S.
Investigative Ophthalmology & Visual Science 2009 Jun; 50(6):2871.
Application：IHC-Fr, Human, Giant Papillae.
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Recruitment of dendritic cells in human liver with metastases.
Gulubova M, Manolova I, Cirovski G, Sivrev D.
Clinical & Experimental Metastasis 2008 Jun; 25(7):777.
Application：IHC-P, Human, Liver.
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A phase I study of immunization using particle-mediated epidermal delivery of genes for gp100 and GM-CSF into uninvolved skin of melanoma patients.
Cassaday RD, Sondel PM, King DM, Macklin MD, Gan J, Warner TF, Zuleger CL, Bridges AJ, Schalch HG, Kim KM, Hank JA, Mahvi DM, Albertini MR.
Clinical Cancer Research 2007 Jan; 13(2 Pt 1):540.
Application：IHC-P, Human, Human skin biopsies.
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Foreign body-type multinucleated giant cells induced by interleukin-4 express select lymphocyte co-stimulatory molecules and are phenotypically distinct from osteoclasts and dendritic cells.
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