CHGA recombinant monoclonal antibody, clone CHGA/1773R
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CHGA.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human CHGA.
Theoretical MW (kDa)
68-75
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas (A) and human parathyroid (B) with CHGA recombinant monoclonal antibody, clone CHGA/1773R (Cat # RAB00321).Immunofluorescence
Flow Cytometry
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Gene Info — CHGA
Entrez GeneID
1113Protein Accession#
P10645Gene Name
CHGA
Gene Alias
CGA
Gene Description
chromogranin A (parathyroid secretory protein 1)
Omim ID
118910Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq
Other Designations
betagranin (N-terminal fragment of chromogranin A)|chromogranin A|parathyroid secretory protein 1
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Interactome
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Disease
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Publication Reference
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Distribution of chromogranin A and secretogranin I (chromogranin B) in neuroendocrine cells and tumors.
Lloyd RV, Cano M, Rosa P, Hille A, Huttner WB.
The American Journal of Pathology 1988 Feb; 130(2):296.
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The primary structure of human chromogranin A and pancreastatin.
Konecki DS, Benedum UM, Gerdes HH, Huttner WB.
The Journal of Biological Chemistry 1987 Dec; 262(35):17026.
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Distribution of chromogranin A and secretogranin I (chromogranin B) in neuroendocrine cells and tumors.
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